Rapid Acclimatisation to High Altitude by Intermittent Hypoxia Training at Sea Level Role of Biochemical Markers

Rapid induction of soldiers to high altitude under emergency situation may lead higher incidence acute mountain sickness (AMS) and other illness. Intermittent Hypoxia Training (IHT) at sea level before going is an approach for rapid acclimatisation. This be helpful reduce the occurrence AMS leads better acclimatisation in shorter duration. The present study evaluates role biochemical markers after IHT actual altitude. participants were Indian Army Personnel (n=30) they divided into two groups control (n=16) exposed (n=14). intermittent hypoxia training was administered 12 per cent Oxygen 4h/day 4 days using normobaric chamber within 24 hrs - 48 subjects airlifted Leh, Ladakh, India 11,700 ft. Preconditioning with beneficial maintaining antioxidant levels ameliorate oxidative stress responsive proteins like Hemeoxygenase -1 (HO-1) Vascular endothelial growth factor (VEGF) cytoprotective proteins, which facilitate acclimatisation, also get benefited by exposure.